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KMID : 1020120050030010013
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Journal of the Korean Academy of Clinical Electrophysiology
2005 Volume.3 No. 1 p.13 ~ p.29
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Effects of Ultrasound on Cell Proliferation from Chicken Articular Cartilage Explants Culture
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Choi Bo-Kyung
Lee Jae-Hyung
Park Jang-Sung
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Abstract
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This study was performed to examine the effects of therapeutic doses of ultrasound on cell migration distance and proliferation of biopsies from articular cartilage. Articular cartilage biopsies were isolated from proximal part of the tibial of chicken, and cultured. Cartilage explants were exposed for a single 5 min to ultrasound with (spatial average-temporal average) at a frequency of 1 MHz. A control group was treated with the ultrasound generator switched off. The cell migration distance and cell proliferation analysis were performed on day 6 after stimulation of ultrasound. The results revealed that ultrasound influenced cell migration distance and cell proliferation in intensity-dependent manner. It was found that ultrasounds at , , and were significantly increase respectively both cell migration distance and cell proliferation (p<0.05). However, cell migration distance and cell proliferation were not affected by exposure ultrasound at and compared with control group. These results suggest that low-intensity ultrasounds at , , and may stimulate cell proliferation of the chondroblasts, and reflect a potential role in cartilage repair.
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KEYWORD
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